Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof

Vanilloid analogues containing resinferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
United States Patent 6,476,076
Lee , et al. November 5, 2002
Abstract
The present invention is related to new vanilloid analogues containing resiniferatoxin pharmacophores, pharmaceutical compositions comprising such analogues, and their uses as vanilloid receptor agonists and potent analgesics. The present invention provides a pharmaceutical composition for treating acute, chronic, inflammatory or neuropathic pains or for treating bladder hypersensitivity.
Inventors: Lee; Jeewoo (Seoul, KR), Oh; Uhtaek (Seoul, KR), Park; Young-Ho (Seoul, KR), Suh; Young-Ger (Seoul, KR), Park; Hyeung-Geun (Seoul, KR), Kim; Hee-Doo (Seoul, KR)
Assignee: Pacific Corporation (KR)
Digital Biotech Co., Ltd. (KR)
Appl. No.: 09/914,000
Filed: August 20, 2001
PCT Filed: February 21, 2000
PCT No.: PCT/KR00/00137
PCT Pub. No.: WO00/50387
PCT Pub. Date: August 31, 2000