Thiazolopyrimidine modulators of TRPV1

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Thiazolopyrimidine modulators of TRPV1
United States Patent Application 20080004253
Kind Code A1
Branstetter; Bryan James ; et al. January 3, 2008
Abstract

Certain TRPV1-modulating thiazolopyrimidine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
Inventors: Branstetter; Bryan James; (Carlsbad, CA) ; Breitenbucher; James Guy; (Escondido, CA) ; Lebsack; Alec D.; (San Diego, CA) ; Xiao; Wei; (San Diego, CA)
Correspondence Name and Address:

PHILIP S. JOHNSON;JOHNSON & JOHNSON
ONE JOHNSON & JOHNSON PLAZA
NEW BRUNSWICK
NJ
08933-7003
US

Serial No.: 824202
Series Code: 11
Filed: June 28, 2007

U.S. Current Class: 514/210.21; 514/217.06; 514/227.8; 514/234.5; 514/252.16; 514/260.1; 540/600; 544/120; 544/255; 544/60
U.S. Class at Publication: 514/210.21; 514/260.1; 514/227.8; 514/234.5; 514/252.16; 514/217.06; 544/60; 544/120; 544/255; 540/600
Intern'l Class: A61K 31/55 20060101 A61K031/55; A61K 31/541 20060101 A61K031/541; A61K 31/5377 20060101 A61K031/5377; A61K 31/519 20060101 A61K031/519; C07D 498/02 20060101 C07D498/02