Edelman et al: Continuous or extended cycle vs. cyclic use of combined contraceptives for contraception.

Review Title: Edelman et al: Continuous or extended cycle vs. cyclic use of combined contraceptives for contraception. The Cochrane Database of Systematic Reviews 2005 Issue 3
Public release date: 20-Jul-2005
Contact: Amy Molnar
amolnar@wiley.com
John Wiley & Sons, Inc.
Pain generated by damage to the nervous system can be treated with antidepressants
Antidepressant drugs such as amitriptyline are effective against a variety of neuropathic pains.
Neuropathic pains result when injury or disease causes damage to the nervous system. These pains can last for months or years after any injury has healed. The damage may be in peripheral nerves that run through the body and limbs, or within the central nervous system in the spine or brain. Patients with this form of pain are frequently given antidepressant drugs, and researchers who have assessed the findings of 50 trials conducted around the world conclude that there is good evidence that at least some of them work well.
The most convincing evidence was for amitriptyline in doses up to 150mg per day, which achieved at least moderate pain relief. It was difficult to assess the value of selective serotonin reuptake inhibitors (SSRIs) as there are few trials in neuropathic pain. The Cochrane Review Authors also found that there was insufficient high quality evidence for them to draw any conclusions about St John's Wort, venlafaxine and L-tryptophan.
"The clinical impression is that antidepressants are effective and this review confirms this belief," said lead author Tiina Saarto who works in Helsinki University Central Hospital, Helsinki, Finland. "If the drug is going to be affective, it normally starts to reduce pain within a few days of starting to take it."
Antidepressants had most effect treating diabetic neuropathy and post-herpetic neuralglia. There was limited evidence that they could also help people with central pain, atypical facial pain and pain after breast cancer treatment. There was a lack of evidence that they helped people with HIV-related neuropathic pain or 'burning mouth syndrome'.