Burning mouth syndrome responsive to pramipexol

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Burning mouth syndrome (BMS) is characterized by burning discomfort or pain in otherwise normal oral mucosa. It is usually refractory. Treatment modalities are scarce. Herein we report one case of primary disabling BMS, previously refractory to multiple regimens, with complete and persistent improvement with pramipexol, a nonergot dopamine agonist which has high selectivity for dopaminergic D2 receptors. We discuss potential pathophysiological implications of our findings.

2008 Jan 25
Stuginski-Barbosa J, Rodrigues GG, Bigal ME, Speciali JG
J Headache Pain