Understanding of Burning Mouth Syndrome - Burning Mouth Syndrome Newsletters

Research data from Hokkaido University update understanding of burning mouth syndrome

2009 FEB 9 -- According to recent research from Sapporo, Japan, "The objective of this study was to evaluate the effectiveness and tolerability of paroxetine in patients with burning mouth syndrome (BMS). In a 12-week open-label, noncomparative, prospective study, 71 subjects with primary BMS were assigned to receive an initial dosage of paroxetine (10 or 20 mg/ day)."

"The dosage was increased to a maximum of 30 mg/ day. Of these patients, 52 were available to examine the efficacy of treatment in this study. The cumulative proportion of responders was 80.8% (42/52). Of those responding, complete remission of pain was observed in 70.4% (19/27) of patients by week 12. The effects of paroxetine were dose-dependent. The incidence of adverse reactions for the initial daily dosage of 10 mg (41%) was significantly lower than that for 20 mg (76%) (chi(2) test). No serious safety issues were observed. About 80% of BMS patients experienced pain reduction with 12 weeks of paroxetine treatment with only minor transient side effects," wrote Y. Yamazaki and colleagues, Hokkaido University.

The researchers concluded: "These results suggest that paroxetine may be useful in the treatment of patients with BMS. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107:e6-e11)'."

Yamazaki and colleagues published their study in Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology (An open-label, noncomparative, dose escalation pilot study of the effect of paroxetine in treatment of burning mouth syndrome. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2009;107(1):E6-E11).

For additional information, contact Y. Yamazaki, Hokkaido University, Graduate School Dental Medical, Kita Ku, Kita 13 Nishi 7, Sapporo, Hokkaido 0608586, Japan.

Publisher contact information for the journal Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology is: Mosby-Elsevier, 360 Park Avenue South, New York, NY 10010-1710, USA.

Keywords: Japan, Sapporo, Antidepressant, Burning Mouth Syndrome, Clinical Trial Research, Oral Medicine, Oral Pathology, Oral Surgery, Paroxetine, Radiology, Selective Serotonin Reuptake Inhibitor, Hokkaido University.

This article was prepared by Biotech Business Week editors from staff and other reports. Copyright 2009, Biotech Business Week via NewsRx.com.