BMJ Clinical Evidence - Burning mouth syndrome
Burning mouth syndrome
Search date February 2007
John Buchanan and Joanna Zakrzewska
INTRODUCTION: Burning mouth syndrome mainly affects women, particularly after the menopause, when its prevalence may be 18–33%.
METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical question: What are the effects
of treatments for burning mouth syndrome? We searched: Medline, Embase, The Cochrane Library, and other important databases up to
February 2007 (BMJ Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this
review).We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines
and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 12 systematic reviews, RCTs, or observational studies that
met our inclusion criteria.We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic
review we present information relating to the effectiveness and safety of the following interventions: anaesthetics (local), antidepressants,
benzodiazepines (topical clonazepam), benzydamine hydrochloride, cognitive behavioural therapy (CBT), dietary supplements, and hormone
replacement therapy (HRT) in postmenopausal women.

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